| Cat.No.: | EAb-2165 |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a recombinant protein corresponding to the N-terminal region of human OGT. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 120 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP: 5 µl per ChIP; ChIP-Seq: 5 µl each; WB: 1:500- 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to serine or threonine residues in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). OGT can glycosylate a large and diverse number of proteins including HCF1, AKT1, MLL5 and histone H2B. It can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Specifically OGT has been shown to interact directly with TET2 and TET3, enzymes that catalyze the oxidation of 5-methylcytosine on DNA. The TET/OGT interaction leads to GlcNAcylation of HCF1, a protein component of the COMPASS complex, which regulates H3K4 methylation and gene expression. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0453 | Human OGG1 4bp deletion Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1883 | O-GlcNAc Monoclonal Antibody | Inquiry |
| EAb-2087 | OGA/O-GlcNAcase Polyclonal Antibody | Inquiry |
| EAb-2165 | OGT/O-GlcNAc transferase Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-3317 | Recombinant OGT protein | Inquiry |
| Related Gene / Proteins | |||
| OGA | OGG1 | OGT | |
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