| Cat.No.: | EAb-1883 |
| Antibody Type: | Monoclonal |
| Immunogen: | This antibody was raised against a peptide containing O-GlcNAc - serine. This antibody recognizes single O-GlcNAc residues in b-O-glycosidic linkage to serine and threonine. |
| Host: | Mouse |
| Isotype: | IgM |
| Purification: | IgM purification |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | IP; WB |
| Species Reactivity: | Not Species Specific |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | O-GlcNAc (b-O-linked N-acetylglucosamine) is a ubiquitous and dynamic post-translational modification present on numerous cytoplasmic and nuclear proteins and is thought to play a regulatory role in numerous cellular processes including homeostatic mechanisms and gene expression. OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residues whereas OGA / O-GlcNAcase (O-linked N-acetylglucosamine (GlcNAc)-ase) is a glycosidase that removes O-GlcNAc. O-GlcNAc modifications have been described to directly regulate the activities of a variety of transcription factors including Sp1, estrogen receptors, STAT5, NF-κB, p53, YY1, Elf-1, c-Myc, Rb, PDX-1, CREB, fork-head, and others. In addition, RNA polymerase II and the basal transcription factors are also extensively modified by O-GlcNAc. O-GlcNAc modification has been reported to suppress or enhance transcription, depending on the promoter and other associated proteins. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0453 | Human OGG1 4bp deletion Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1883 | O-GlcNAc Monoclonal Antibody | Inquiry |
| EAb-2087 | OGA/O-GlcNAcase Polyclonal Antibody | Inquiry |
| EAb-2165 | OGT/O-GlcNAc transferase Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-3317 | Recombinant OGT protein | Inquiry |
| Related Gene / Proteins | |||
| OGA | OGG1 | OGT | |
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