| Cat.No.: | PE-3317 |
| Product Overview: | Recombinant mouse OGT was expressed in a baculovirus expression system as the full length protein (accession number NP_001277464.1) with an N-terminal DYKDDDDK-Tag. The molecular weight of the protein is 118.7 kDa. The purity of OGT protein is >90 by SDS-PAGE. |
| Background: | OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to serine or threonine residues in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). OGT can glycosylate a large and diverse number of proteins including HCF1, AKT1, MLL5 and histone H2B. It can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Specifically OGT has been shown to interact directly with TET2 and TET3, enzymes that catalyze the oxidation of 5-methylcytosine on DNA. The TET/OGT interaction leads to GlcNAcetylation of HCF1, a protein component of the COMPASS complex, which regulates H3K4 methylation and gene expression. |
| Applications: | Suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Mouse |
| Formulation: | 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. |
| Tag: | DYKDDDDK |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0453 | Human OGG1 4bp deletion Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1883 | O-GlcNAc Monoclonal Antibody | Inquiry |
| EAb-2087 | OGA/O-GlcNAcase Polyclonal Antibody | Inquiry |
| EAb-2165 | OGT/O-GlcNAc transferase Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-3317 | Recombinant OGT protein | Inquiry |
| Related Gene / Proteins | |||
| OGA | OGG1 | OGT | |
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