CtIP Monoclonal Antibody

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Cat.No.:	EAb-2024
Antibody Type:	Monoclonal
Immunogen:	This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.
Host:	Mouse
Isotype:	IgG1
Molecular Weight:	120 kDa
Purification:	Protein A Chromatography
Appearance:	Liquid
Formulation:	Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.
Applications:	IP; ICC/IF; WB
Species Reactivity:	Human
Storage:	-20°C
Warning:	For Research Use Only! Not For Use in Humans.

Scientific Background:

CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.

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Related Gene / Proteins
CTBP	CTBP2	CTCF	CTCFL
CTDSP1	CTDSPL	CtIP	ctnnb1
CTSL1

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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