| Cat.No.: | EAb-1999 |
| Antibody Type: | Polyclonal |
| Immunogen: | This ETO / RUNX1T1 antibody was raised against a peptide within the internal region of human ETO / RUNX1T1. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 68 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | IP: 10 µl per IP; WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | ETO / RUNX1T1 (AML1T1, CBFA2T1, MTG8, ZMYND2) belongs to a family of evolutionarily conserved nuclear factors that act as a transcriptional corepressor. ETO / RUNX1T1 does not interact directly with DNA but is recruited by transcription factors such as PLZF, BCL6, TAL1/SCL, Gfi1and Heb recruit nuclear co-repressors such as NCoR, SIN3, and SMRT / NCoR2, which in turn interact with histone deacetylase (HDAC) to mediate transcriptional repression. ETO / RUNX1T1 contains four evolutionarily conserved functional domains called nervy homology regions (NHRs) involved in protein-protein interaction. ETO / RUNX1T1 is frequently found as a fusion partner of AML1 in acute myeloid leukemia with the t(8;21) translocation which gives rise to the AML-ETO fusion protein. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0105 | Recombinant Human ETS1 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0139 | ETO Polyclonal Antibody | Inquiry |
| EAb-0195 | ERM/ ETV5 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0804 | Recombinant Human ETS1 | Inquiry |
| PE-0805 | Recombinant Human ETS1 | Inquiry |
| Related Gene / Proteins | |||
| ETO | ETR3 | ETS1 | ETV5 |
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