| Cat.No.: | EAb-0139 |
| Product Overview: | Polyclonal Antibody to detect ETO in human samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | Polyclonal antibody against human ETO using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | ETO |
| Purification: | Whole Anti-Sera |
| Appearance: | Colorless liquid |
| Formulation: | In PBS with 0.05% (W/V) sodium azide. |
| Applications: | ELISA, ChIP. |
| Recommended Dilutions/Conditions: |
ChIP: 4 µl/ChIP, ELISA: 1:100. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | ELISA: Peptides, ChIP: SKNO-1 cells. |
| Species Reactivity: | Human |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q06455 |
| Alternative Name: | RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2 |
| Scientific Background: | ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t (8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5’-region of AML1 and the 3’-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0105 | Recombinant Human ETS1 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0139 | ETO Polyclonal Antibody | Inquiry |
| EAb-0195 | ERM/ ETV5 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0804 | Recombinant Human ETS1 | Inquiry |
| PE-0805 | Recombinant Human ETS1 | Inquiry |
| Related Gene / Proteins | |||
| ETO | ETR3 | ETS1 | ETV5 |
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