ChIP-seq Service

Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) is the gold-standard technique for mapping protein–DNA interactions and histone modifications genome-wide. CD BioSciences offers a full suite of ChIP-seq services tailored to different sample types, targets, and research questions. Our optimized protocols and deep analytical pipelines deliver publication-ready insights for epigenetics, transcriptional regulation, disease mechanism studies, and therapeutic discovery.

Introduction to ChIP-seq

ChIP-seq combines immunoprecipitation of crosslinked protein–DNA complexes with high-throughput sequencing to identify genomic binding sites of transcription factors, histone modifications, and chromatin-associated proteins. By analyzing where these factors are bound or enriched across the genome, researchers can infer:

1. Active and repressed chromatin states
2. Enhancer and promoter usage
3. Core regulatory circuits
4. Transcriptional dynamics and pausing
5. Drug-responsive or disease-linked epigenomic changes

ChIP-seq is compatible with a wide range of experimental designs, from basic cell biology to translational tissue profiling.

Fig.1 ChIP-seq analysis workflow. (Nakato, R., et al., 2021)

Our Services

To address the wide spectrum of research questions in transcriptional regulation and epigenetics, CD BioSciences offers multiple specialized ChIP-seq services. Each module is designed with optimized protocols, target-specific workflows, and tailored analysis strategies to meet the distinct needs of different chromatin targets and sample types.

Supported Sample Types

1. Purified Genomic DNA
2. Cultured Cells (e.g., mammalian)
3. Fresh-Frozen Tissue

1. FFPE Tissue Sections
2. Low-Input and Micro-Dissected Samples
3. Other Types (Please Inquire)

Why Choose Us?

1. Target-specific protocol optimization
2. Validated antibody recommendations and controls
3. Tissue, cell line, or low-input compatibility
4. FFPE sample support and clinical tissue workflows
5. High reproducibility and signal-to-noise QC thresholds
6. Clear data outputs with integration-ready formats (ChIP-seq + RNA-seq, ATAC-seq, etc.)

Start mapping the epigenomic landscape of your system. Whether you're investigating transcriptional regulation, enhancer logic, chromatin states, or therapeutic mechanisms, CD BioSciences's ChIP-seq platform offers the versatility and resolution your research demands. Explore our ChIP-seq modules or contact us to build your custom project plan.

Reference

1. Nakato, R., & Sakata, T. (2021). Methods for ChIP-seq analysis: A practical workflow and advanced applications. Methods (San Diego, Calif.), 187, 44–53.