| Cat.No.: | PE-1479 |
| Product Name: | Recombinant Human CENPA, His-tagged |
| Product Overview: | Recombinant Full Length Human CENPA produced in Sf9 Insect cells with a 6x His tag, 17,015 Dalton. |
| Description: | Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | >90% by SDS-PAGE |
| Species: | Human |
| Tag: | His |
| Sequence Similarities: | Belongs to the histone H3 family. |
| Activity: | CENPA-27391TH reacts with Scleroderma patient sera. |
| Expression System: | Sf9 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | CENPA centromere protein A [ Homo sapiens ] |
| Gene ID NCBI: | 1058 |
| Official Symbol: | CENPA |
| Synonyms: | CENPA; centromere protein A; centromere protein A (17kD) , centromere protein A, 17kDa; histone H3-like centromeric protein A; CENP A; |
| mRNA Refseq: | NM_001042426 |
| Protein Refseq: | NP_001035891 |
| MIM: | 117139 |
| UniProt ID: | P49450 |
| Chromosome Location: | 2p24-p21 |
| Function: | DNA binding; chromatin binding; protein binding; |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0054 | Human CECR2 Knockout Cell Line 13bp deletion | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0191 | Human CENPA peptide | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0219 | Recombinant Human CENPA 293 Cell Lysate | Inquiry |
| EL-0220 | Recombinant Human CENPA 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0340 | NVS-CECR2-1 | Inquiry |
| Related Gene / Proteins | |||
| CEACAM1 | CECR1 | CECR2 | CELF-5 |
| CELF-6 | CENH3 | CENPA | CENPB |
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