| Cat.No.: | PE-1348 |
| Product Overview: | Recombinant SAP18 protein was expressed in E.coli and purified by using conventional chromatography techniques. MW =19.7 kDa (173 aa). |
| Description: | SAP18, also known as Sin3A-associated protein, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | > 90% by SDS – PAGE. |
| Species: | Human |
| Formulation: | Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY |
| Endotoxin: | < 1.0 EU per 1 μg of protein (determined by LAL method ). |
| Expression System: | E. coli |
| Concentrations: | 0.5 mg/ml (determined by Bradford assay). |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SAP18 Sin3A-associated protein, 18kDa [ Homo sapiens ] |
| Gene ID NCBI: | 10284 |
| Synonyms: | SAP18; Sin3A-associated protein, 18kDa; SAP18P; 2HOR0202; MGC27131; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; histone deacetlyase complex subunit SAP18; sin3A-associated protein, 18kDa; SAP18p; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide, 18 kDa; Sin3-associated polypeptide p18; Cell growth-inhibiting protein 38; GIG38; OTTHUMP00000018107 |
| mRNA Refseq: | NM_005870 |
| Protein Refseq: | NP_005861 |
| MIM: | 602949 |
| UniProt ID: | O00422 |
| Chromosome Location: | 13q12.11 |
| Function: | protein binding; transcription corepressor activity |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0034 | SALL1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0058 | 3-Deazaadenosine | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0152 | Recombinant Human SAP30L 293 Cell Lysate | Inquiry |
| EL-0155 | Recombinant Human SAP30BP 293 Cell Lysate | Inquiry |
| EL-0164 | Recombinant Human SAP30 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SAH | SALL1 | SALL4 | SAP130 |
| SAP145 | SAP18 | SAP30 | SAP30BP |
| SAP30L | SART3 | SATB1 | SATB2 |
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