| Cat.No.: | PE-1245 |
| Product Name: | Recombinant Human EP300 protein, DDK-tagged |
| Product Overview: | Recombinant Human EP300(Tyr1066-Lys1707) fused with DDK tag at C-terminal was expressed in Insect cells. |
| Description: | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 75 kDa |
| Purity: | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Species: | Human |
| Formulation: | 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol. Store at -80 centigrade. |
| Tag: | DDK |
| Expression System: | Insect Cells |
| Protein Length: | Tyr1066-Lys1707 |
| Concentrations: | >50 ug/mL as determined by microplate BCA method |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | EP300 E1A binding protein p300 [ Homo sapiens ] |
| Gene ID NCBI: | 2033 |
| Official Symbol: | EP300 |
| Synonyms: | EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2; |
| mRNA Refseq: | NM_001429 |
| Protein Refseq: | NP_001420 |
| MIM: | 602700 |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| BSM-0108 | Curcumin, Curcuma longa (High Purity) | Inquiry |
| ◆ Cell Lines | ||
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EP300 | EPC1 | ||
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