| Cat.No.: | PE-1235 |
| Product Name: | Recombinant Human E1A Binding Protein P300, GST-tagged |
| Product Overview: | Recombinant human EP300 (532-1153; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein that functions as a histone acetyltransferase. EP300 regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. EP300 binding is a highly accurate process and can be used for identifying enhancers and their associated activities. EP300 is also useful in the study of the role of tissue-specific enhancers in human biology and diseases on a genome wide scale. Defects in EP300 gene are a cause of Rubinstein-Taybi syndrome that play a important role in epithelial cancer and act as a classic tumor suppressor gene. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 120 kDa |
| Purity: | > 80 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 532-1153; contains the catalytic domain |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | EP300 E1A binding protein p300 [ Homo sapiens ] |
| Gene ID NCBI: | 2033 |
| Official Symbol: | EP300 |
| Synonyms: | EP300; E1A binding protein p300; p300; KAT3B; RSTS2; histone acetyltransferase p300; p300 HAT; E1A-binding protein, 300Kd; E1A-associated protein p300; OTTHUMP00000198754 |
| mRNA Refseq: | NM_001429 |
| Protein Refseq: | NP_001420 |
| MIM: | 602700 |
| UniProt ID: | Q09472 |
| Chromosome Location: | 22q13.2 |
| Function: | DNA binding; NF-kappaB binding; RNA polymerase II activating transcription factor binding; SMAD binding; acetyltransferase activity; activating transcription factor binding; acyltransferase activity; bHLH transcription factor binding; glucocorticoid receptor binding; histone acetyltransferase activity; metal ion binding; peroxisome proliferator activated receptor binding; transcription coactivator activity; contributes_to transcription coactivator activity; zinc ion binding |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| BSM-0108 | Curcumin, Curcuma longa (High Purity) | Inquiry |
| ◆ Cell Lines | ||
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EP300 | EPC1 | ||
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