| Cat.No.: | PE-1029 |
| Product Name: | Recombinant Human SUV39H1, GST-tagged |
| Product Overview: | Recombinant Human SUV39H1 (amino acids 82-412) was expressed in an E.coli expression system with N-terminal GST tag. MW=64 kDa. |
| Description: | Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | > 50%. |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) [ Homo sapiens ] |
| Gene ID NCBI: | 6839 |
| Synonyms: | suppressor of variegation 3-9 homolog 1 (Drosophila); MG44; KMT1A; SUV39H; SUV39H1; suppressor of variegation 3-9 homolog 1; H3-K9-HMTase 1; Su(var)3-9 homolog 1; histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; EC 2.1.1.43; OTTHUMP00000024298Histone; H3-K9 methyltransferase 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1; suppressor of variegation 3-9 (Drosophila) homolog 1 |
| mRNA Refseq: | NM_003173 |
| Protein Refseq: | NP_003164 |
| MIM: | 300254 |
| UniProt ID: | O43463 |
| Chromosome Location: | Xp11.23 |
| Function: | S-adenosylmethionine-dependent methyltransferase activity; chromatin binding; histone methyltransferase activity (H3-K9 specific); protein N-terminus binding; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0020 | Suz12 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0100 | Chaetocin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0103 | Recombinant Human SUZ12 293 Cell Lysate | Inquiry |
| EL-0132 | Recombinant Human SUV39H1 293 Cell Lysate | Inquiry |
| EL-0137 | Recombinant Human SUV420H1 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SUDS3 | SUMO | SUMO1 | SUMO2 |
| SUMO3 | SUN1 | Surf6 | suv39h1 |
| SUV39H2 | SUV3L1 | SUV420H1 | SUV420H2 |
| SUZ12 | |||
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