| Cat.No.: | PE-0819 |
| Product Name: | Recombinant Human PCNA, His-tagged |
| Product Overview: | Recombinant Human PCNA (Met 1-Ser 261) fused with a polyhistidine tag at the N-terminus, was expressed in Baculovirus-Insect cells. |
| Description: | The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | Predicts a molecular mass of 31KDa. It migrates as an approximately 36 KDa band in SDS-PAGE under reducing conditions. |
| Purity: | > 90 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile 50mM Na3PO4, 300mM NaCl, 10%glycerol, pH 7.0, 2mM DTT |
| Tag: | His |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Reconstitution: | A hardcopy of COA with reconstitution instruction is sent along with the products. |
| Expression System: | Baculovirus-Insect Cells |
| Protein Length: | 280 amino acids |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | PCNA proliferating cell nuclear antigen [ Homo sapiens ] |
| Gene ID NCBI: | 5111 |
| Synonyms: | MGC8367; PCNA; Proliferating cell nuclear antigen; Cyclin; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein |
| mRNA Refseq: | NM_002592 |
| Protein Refseq: | NP_002583 |
| MIM: | 176740 |
| UniProt ID: | P12004 |
| Chromosome Location: | 20pter-p12 |
| Function: | DNA binding; DNA polymerase processivity factor activity; MutLalpha complex binding; dinucleotide insertion or deletion binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0039 | Embelin | Inquiry |
| BSM-0108 | Curcumin, Curcuma longa (High Purity) | Inquiry |
| BSM-0133 | Garcinol | Inquiry |
| ◆ Antibodies | ||
| EAb-0060 | PCAF Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0106 | Recombinant Human PCNA Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| PCAF | PCBP2 | PCBP3 | PCBP4 |
| PCGF2 | PCGF6 | PCL2 | PCNA |
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