| Cat.No.: | PE-0631 |
| Product Name: | Recombinant Human NCOR1, FLAG-tagged |
| Product Overview: | Recombinant full length human Nuclear Receptor Corepressor NCoR with DDDDK tag expressed in Baculovirus system; amino acids 1-2440, 270kDa. |
| Description: | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | >95% by SDS-PAGE |
| Species: | Human |
| Tag: | Flag |
| Sequence Similarities: | Belongs to the N-CoR nuclear receptor corepressors family.Contains 2 SANT domains. |
| Activity: | NCOR1-28430TH has been tested for deacetylation activity in vitro in the presence of HDAC3. |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ] |
| Gene ID NCBI: | 9611 |
| Official Symbol: | NCOR1 |
| Synonyms: | NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; |
| mRNA Refseq: | NM_001190438 |
| Protein Refseq: | NP_001177367 |
| MIM: | 600849 |
| UniProt ID: | O75376 |
| Chromosome Location: | 17p11.2 |
| Function: | histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
| ◆ Antibodies | ||
| EAb-0065 | NCOA1 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0143 | Recombinant Human NCOA1 293 Cell Lysate | Inquiry |
| EL-0144 | Recombinant Human NCOA2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
| NCOA3 | NCoA4 | NCOR1 | ncor2 |
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