| Cat.No.: | PE-0392 |
| Product Name: | Recombinant Human Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 2, His-tagged |
| Product Overview: | Recombinant CITED2 protein, fused to His-tagged, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 29.5 kDa. |
| Description: | CITED2 is an important transcriptional cofactor involved in multiple organ development. It is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1a through its competitive binding with HIF-1a to CBP/p300. CITED2 is necessary for mouse fetal liver hematopoiesis and is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. |
| Applications: | SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 29.5 kDa (278 aa), confirmed by MALDI-TOF. |
| Purity: | >90% by SDS - PAGE |
| Species: | Human |
| Formulation: | Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 50% glycerol, 1mM DTT. |
| Tag: | His |
| Amino Acid Sequence: | MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH |
| Endotoxin: | < 1.0 eu per 1 μg of protein (determined by LAL test) |
| Expression System: | E. coli |
| Protein Length: | 1-270aa |
| Concentrations: | 0.25 mg/ml (determined by Bradford assay) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 [ Homo sapiens ] |
| Gene ID NCBI: | 10370 |
| Synonyms: | CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; cbp/p300-interacting transactivator 2; MRG1; MRG-1; MSG1-related gene 1; MSG-related protein 1; melanocyte-specific gene 1-related gene 1; ASD8; VSD2; P35SRJ; |
| mRNA Refseq: | NM_001168388 |
| Protein Refseq: | NP_001161860 |
| MIM: | 602937 |
| UniProt ID: | Q99967 |
| Chromosome Location: | 6q23.3 |
| Function: | LBD domain binding; RNA polymerase II activating transcription factor binding; SMAD binding; chromatin binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription corepressor activity; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0040 | Recombinant Human CITED2 Cell Lysate | Inquiry |
| EL-0114 | Recombinant Human CITED1 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0387 | Human CIB1 Knockout Cell Line | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0389 | Recombinant Human CITED2, His-tagged | Inquiry |
| PE-0390 | Recombinant Human CITED2, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| CIB1 | CIRP | CITED1 | CITED2 |
| CIZ1 | |||
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