| Cat.No.: | PE-0389 |
| Product Overview: | Recombinant Human CITED2 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 278 amino acids (1-270 a.a.) and having a molecular mass of 29.5 kDa. The CITED2 is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques. |
| Description: | CITED2 is a significant transcriptional cofactor that takes part in multiple organ development. CITED2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a negative regulator for HIF1A through its competitive binding with HIF1A to CBP/p300. CITED2 is essential for mouse fetal liver hematopoiesis and is necessary for the appropriate formation of the hyaloid vasculature and for lens morphogenesis. CITED2 is a coactivator of HNF4alpha and necessary for liver development. CITED2 is a coactivator of PPAR-alpha and both participate in signaling cascades of hypoxic response and angiogenesis. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Sterile Filtered colorless solution. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | The CITED2 solution contains 20mM Tris pH-8, 1mM DTT, 0.1M NaCl & 40% glycerol. |
| Tag: | His |
| Amino Acid Sequence: | MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 [ Homo sapiens ] |
| Gene ID NCBI: | 10370 |
| Synonyms: | CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; MRG1; P35SRJ; MSG-related protein 1; P35srj; Cbp/p300-interacting transactivator 2 |
| mRNA Refseq: | NM_006079 |
| Protein Refseq: | NP_006070 |
| MIM: | 602937 |
| Chromosome Location: | 6q23.3 |
| Function: | protein binding; transcription coactivator activity; transcription factor activity |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0040 | Recombinant Human CITED2 Cell Lysate | Inquiry |
| EL-0114 | Recombinant Human CITED1 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0387 | Human CIB1 Knockout Cell Line | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0389 | Recombinant Human CITED2, His-tagged | Inquiry |
| PE-0390 | Recombinant Human CITED2, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| CIB1 | CIRP | CITED1 | CITED2 |
| CIZ1 | |||
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