| Cat.No.: | PE-0255 |
| Product Name: | Recombinant Human EED protein, His-tagged |
| Product Overview: | Recombinant full-length human EED was expressed in E.coli cells using an N-terminal His tag. |
| Description: | The embryonic ectoderm development protein (EED), a WD40 domain-containing protein, is the regulatory subunit of polycomb repressive complex 2 (PRC2). PRC2 catalyzes the monomethylation, dimethylation, and trimethylation of histone H3 Lys27 (H3K27) and acts as a central epigenetic regulator that marks the repressive chromatin domain. EED binds to the tri-methylated lysine 27 of the histone H3 (H3K27me3), and through which stimulates the activity of PRC2 allosterically. |
| Applications: | Enzyme Assay; WB |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 57 kDa |
| Purity: | The purity of EED was determined to be >90% by densitometry. |
| Species: | Human |
| Formulation: | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol |
| Tag: | His |
| Expression System: | E. coli |
| Concentrations: | 0.1 μg/μL |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | embryonic ectoderm development [ Homo sapiens (human) ] |
| Gene ID NCBI: | 8726 |
| Official Symbol: | EED |
| Synonyms: | HEED; WAIT1 |
| mRNA Refseq: | NM_003797 |
| Protein Refseq: | NP_003788 |
| MIM: | 605984 |
| UniProt ID: | O75530 |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0026 | Recombinant Human EED Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0166 | MAK-683 | Inquiry |
| ◆ Research Kits | ||
| EKIT-0182 | EZH2-EED Binding Assay Kit | Inquiry |
| ◆ Antibodies | ||
| EAb-0196 | EEF1A Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0248 | Recombinant Human EED, His & GST tagged | Inquiry |
| Related Gene / Proteins | |||
| EED | EEF1A1 | EEF1A2 | EEF1B2 |
| EEF1G | |||
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