| Cat.No.: | PE-0101 |
| Product Name: | Recombinant Human HDAC8, His-tagged |
| Product Overview: | Recombinant full length protein (Human), C-terminal His tag. |
| Description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Tissue Specificity: | Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | >90% by SDS-PAGE |
| Species: | Human |
| Tag: | His |
| Sequence Similarities: | Belongs to the histone deacetylase family. HD type 1 subfamily. |
| Activity: | 10 U/ug. One U =1 pmol/min, Assay condition: 25 mM Tris/Cl,pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 100 uM Biomol substrate, and 15 ng/ul HDAC8. Incubation condition: 60 min at 30℃. |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC8 histone deacetylase 8 [ Homo sapiens ] |
| Gene ID NCBI: | 55869 |
| Official Symbol: | HDAC8 |
| Synonyms: | HDAC8; histone deacetylase 8; HDACL1, histone deacetylase like 1; RPD3; |
| mRNA Refseq: | NM_001166418 |
| Protein Refseq: | NP_001159890 |
| MIM: | 300269 |
| UniProt ID: | Q9BY41 |
| Chromosome Location: | Xq13 |
| Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 spe; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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