| Cat.No.: | PE-0055 |
| Product Name: | Recombinant Human Distone Deacetylase 4, GST-tagged |
| Product Overview: | Recombinant human HDAC4 (612-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | HDAC4 or Histone Deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity. |
| Applications: | HDAC Assay; Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 77 kDa |
| Purity: | >95% |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Tag: | GST |
| Activity: | 60 RLU/min/ng |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 612-end |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC4 histone deacetylase 4 [ Homo sapiens ] |
| Gene ID NCBI: | 9759 |
| Official Symbol: | HDAC4 |
| Synonyms: | HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288; histone deacetylase 4; OTTHUMP00000164483; histone deacetylase A |
| mRNA Refseq: | NM_006037 |
| Protein Refseq: | NP_006028 |
| MIM: | 605314 |
| UniProt ID: | P56524 |
| Chromosome Location: | 2q37 |
| Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; histone deacetylase binding; protein binding; protein deacetylase activity; repressing transcription factor binding; contributes_to sequence-specific DNA binding; contributes_to transcription regulatory region DNA binding; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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