| Cat.No.: | PE-0012 |
| Product Name: | Recombinant Human Histone Deacetylase 1, His-tagged |
| Product Overview: | HDAC1 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.Full Length Human HDAC1 – Class I, 59 kD with his tag. |
| Description: | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Species: | Human |
| Purification: | Ni2+ Affinity Column |
| Formulation: | 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol |
| Tag: | His |
| Activity: | 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug at pH8 at 30℃. |
| Expression System: | Baculovirus-Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC1 histone deacetylase 1 [ Homo sapiens ] |
| Gene ID NCBI: | 3065 |
| Synonyms: | HDAC1; DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1; histone deacetylase 1; OTTHUMP00000008745; reduced potassium dependency, yeast homolog-like 1; DKFZp686H12203; EC 3.5.1.98. |
| mRNA Refseq: | NM_004964 |
| Protein Refseq: | NP_004955 |
| MIM: | 601241 |
| UniProt ID: | Q13547 |
| Chromosome Location: | 1p34 |
| Function: | enzyme binding; histone deacetylase activity; hydrolase activity; identical protein binding; transcription activator activity; transcription factor activity; transcription factor binding; transcription factor binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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