| Cat.No.: | EAb-2963 |
| Product Name: | Aurora B Monoclonal Antibody (AURKB/1521) |
| Product Overview: | Mouse monoclonal (AURKB/1521) to detect Aurora B |
| Antibody Type: | Monoclonal |
| Clone Designation: | AURKB/1521 |
| Immunogen: | Recombinant fragment within Human Aurora B aa 89-251. |
| Host: | Mouse |
| Isotype: | IgG2b |
| Purification: | Protein A/G purified |
| Appearance: | Liquid |
| Formulation: | 0.05% Sodium azide, 0.05% BSA, 99% PBS |
| Applications: | WB |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q96GD4 |
| Alternative Name: | AIK2 antibody/AIM-1 antibody/AIM1 antibody |
| Scientific Background: | May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP. |
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