gamma H2A.X pS139 Polyclonal Antibody - ChIP Grade

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Cat.No.:  EAb-2920
Product Name:  gamma H2A.X pS139 Polyclonal Antibody - ChIP Grade
Product Overview:  Rabbit polyclonal to detect gamma H2A.X (phospho S139) - ChIP Grade
Antibody Type:  Polyclonal
Immunogen:  Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human gamma H2A.X, phosphorylated at S139.
Host:  Rabbit
Isotype:  IgG
Purification:  Immunogen affinity purified
Appearance:  Liquid
Formulation:  0.02% Sodium Azide
Applications:  IHC-FoFr, IP, ICC, ICC/IF, IHC-P, ChIP/Chip, ChIP, WB
Species Reactivity:  Mouse, Rat, Human
Storage:  -20°C.
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  H2A histone family member X antibody/H2A histone family member X antibody/H2A.FX antibody
Scientific Background:  Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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