| Cat.No.: | EAb-2552 |
| Product Overview: | Rabbit polyclonal to detect ADAR1 |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthetic peptide, corresponding to a region within amino acids 200-250 of Human ADAR1 |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | 0.09% Sodium azide, 99% Tris citrate/phosphatepH 7 to 8 |
| Applications: | IHC-P, WB, IP |
| Species Reactivity: | Human |
| Storage: | +4°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | NP_001102.2 |
| Alternative Name: | 136 kDa double-stranded RNA-binding protein antibody/136kDa double stranded RNA binding protein antibody/Adar 1 antibody |
| Scientific Background: | Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0203 | ADNP Polyclonal Antibody | Inquiry |
| EAb-0370 | ADPRHL2 Polyclonal Antibody | Inquiry |
| ◆ Research Kits | ||
| EKIT-0580 | ADMA direct (mouse/rat) ELISA kit | Inquiry |
| EKIT-0581 | ADMA (human) ELISA kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2174 | Recombinant Human ADAL protein (denatured) | Inquiry |
| Related Gene / Proteins | |||
| ADA | ADAL | ADAR1 | ADMA |
| ADNP | ADPRH | ADPRHL2 | |
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