| Cat.No.: | EAb-2529 |
| Product Overview: | Mouse polyclonal to detect ADAR1 |
| Antibody Type: | Polyclonal |
| Immunogen: | Full length protein, corresponding to amino acids 1-1226 of Human ADAR1(P55265) |
| Host: | Mouse |
| Isotype: | IgG |
| Purification: | Protein A purified |
| Appearance: | Liquid |
| Formulation: | pH: 7.20, 2.68% PBS |
| Applications: | WB, IHC-P, ICC/IF |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | 136 kDa double-stranded RNA-binding protein antibody/136kDa double stranded RNA binding protein antibody/Adar 1 antibody |
| Scientific Background: | Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0203 | ADNP Polyclonal Antibody | Inquiry |
| EAb-0370 | ADPRHL2 Polyclonal Antibody | Inquiry |
| ◆ Research Kits | ||
| EKIT-0580 | ADMA direct (mouse/rat) ELISA kit | Inquiry |
| EKIT-0581 | ADMA (human) ELISA kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2174 | Recombinant Human ADAL protein (denatured) | Inquiry |
| Related Gene / Proteins | |||
| ADA | ADAL | ADAR1 | ADMA |
| ADNP | ADPRH | ADPRHL2 | |
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