| Cat.No.: | EAb-2395 |
| Product Name: | Aurora B Polyclonal Antibody |
| Product Overview: | Rabbit polyclonal to detect Aurora B |
| Antibody Type: | Polyclonal |
| Immunogen: | This Aurora B antibody was raised against a peptide including the C-terminus of human Aurora B. |
| Host: | Rabbit |
| Isotype: | Serum |
| Molecular Weight: | 49 kDa |
| Purification: | None |
| Appearance: | Liquid |
| Formulation: | Rabbit serum containing 30% glycerol and 0.035% sodium azide. |
| Applications: | ICC/IF: 1:200 - 1:1,000 dilution; WB: 1:500 - 1:5,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Wide Range Predicted |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q96GD4 |
| Alternative Name: | AURKB; AIK2; AIM-1; AIM1; ARK2; AurB; IPL1; PPP1R48; STK12; STK5; aurkb-sv1; aurkb-sv2; aurora kinase B |
| Scientific Background: | Aurora B (Aurora Kinase B, AurB, ARK2) is a Ser/Thr kinase that is part of the chromosomal passenger complex that associates with chromosomes and is an important regulator of mitosis and meiosis. Aurora B becomes concentrated at the centromere during the onset of mitosis, but relocates to the spindle midzone during anaphase. Aurora B phosphorylates a number of substrates, including INCENP, CENP-A, and Histone H3. Misregulation of Aurora B activity can lead to chromosome instability and is implicated in a number of cancers. |
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