| Cat.No.: | EAb-2307 |
| Antibody Type: | Polyclonal |
| Immunogen: | This 3-methylcytosine antibody was raised against 3-methylcytidine conjugated to KLH and recognizes 3-methylcytosine . |
| Host: | Rabbit |
| Isotype: | Serum |
| Purification: | None |
| Appearance: | Liquid |
| Formulation: | Rabbit serum containing 30% glycerol and 0.035% sodium azide. |
| Applications: | DB: 1:1,000 - 1:10,000 dilution; ICC/IF^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Not Species Specific |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Methylation of DNA can occur non-enzymatically at the nitrogen-three of the cytosine base through spontaneous exposure to endogenous S-adenosyl methionine (SAM). The resulting 3-methylcytosine (3-mC) is mutagenic and must be repaired, which occurs in humans through the base excision repair (BER) or dealkylation via human homologues of the E. coli AlkB protein. 3-methylcytosine is present in human cell lines and increased levels of 3-mC impair proliferation. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-2307 | 3-Methylcytosine (3-mC) Polyclonal Antibody | Inquiry |
| EAb-2308 | 3-Methylcytosine (3-mC) Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| 3-mC | |||
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