| Cat.No.: | EAb-2112 |
| Antibody Type: | Polyclonal |
| Immunogen: | This Drosha antibody was raised against a peptide within the C-terminal region of human Drosha. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 160 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | IP: 10 µl per IP; WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Drosha is an RNAse III enzyme that is involved in the process of generating microRNA (miRNA). miRNA interacts with the RNA-induced silencing complex (RISC) to cleave mRNA and thus downregulate gene expression. Drosha is a double stranded RNAse and part of the Microprocessor complex. Other RNAse III enzymes include Dicer and Argonaute. Drosha initiates processing of the miRNA precursor (pri-miRNA) in the nucleus, which is then exported to the cytoplasm and further cleaved by Dicer into a mature miRNA. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-2007 | DR4 Monoclonal Antibody | Inquiry |
| EAb-2008 | DR6 Polyclonal Antibody | Inquiry |
| EAb-2112 | Drosha Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| DR4 | DR6 | Drosha | |
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