| Cat.No.: | EAb-2050 |
| Antibody Type: | Monoclonal |
| Immunogen: | This BMI-1 antibody was raised against a recombinant protein corresponding to full-length mouse BMI-1. |
| Host: | Mouse |
| Isotype: | IgG2a |
| Molecular Weight: | 40 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP-Seq: 4 µg per ChIP; WB: 0.5 - 2 µg/mL; ChIP; IHC (FFPE); IF^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P35226 |
| Alternative Name: | Polycomb group RING finger protein 4, RING finger protein 51 |
| Scientific Background: | BMI-1 is a member of the Polycomb PRC1 complex that is recruited to transcriptionally repressed genes subsequent to histone H3 lysine 27 methylation in order to maintain repression. In the PRC1 complex, BMI-1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2, resulting in the ubiquitylation of histone H2A at lysine 119. BMI-1 acts as an oncogene and cooperates with c-myc in the initiation of lymphoma. High levels of expression of BMI-1 are observed in metastatic melanoma, and BMI-1 has been implicated in several other cancers. BMI-1 is required for hematopoietic stem cell self renewal. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0033 | Human COMMD3-BMI1 Knockout Cell Line | Inquiry |
| CL-0034 | Human BMI1 Knockout Cell Line 11bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0164 | BMI1 Polyclonal Antibody | Inquiry |
| EAb-0165 | BMI1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0319 | PTC-209 | Inquiry |
| Related Gene / Proteins | |||
| BMI1 | |||
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