| Cat.No.: | EAb-2028 |
| Antibody Type: | Polyclonal |
| Immunogen: | This CoREST antibody was raised against a synthetic peptide derived from the C-terminal region of human CoREST. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 66 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:1,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | CoREST (REST corepressor 1, RCOR1) is a corepressor protein recruited by the REST, a neuronal gene-specific transcriptional repressor, to help repress neuron specific gene expression in non-neuronal cell lineages. CoREST is an essential component of the BHC repressor complex that also contains HDAC1, HDAC2, HMG20B/BRAF35, LSD1 (a lysine-4 specific histone demethylase) and PHF21A/BHC80. The Herpes Simplex virus ICP0 protein blocks the repression of viral genes by disrupting the interaction between CoREST and HDAC1/2. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0033 | Human COMMD3-BMI1 Knockout Cell Line | Inquiry |
| CL-0262 | Human COPS6 Knockout Cell Line 40bp deletion | Inquiry |
| CL-0271 | Human COPS7A Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0212 | Recombinant Human C17orf79 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0278 | Entacapone | Inquiry |
| Related Gene / Proteins | |||
| COMMD2 | COMMD3 | COMMD4 | COMMD6 |
| COMMD9 | COMT | COP1 | COPRS |
| COPS6 | COPS7A | COPS7B | CoREST |
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