| Cat.No.: | EAb-2018 |
| Product Name: | SMRT / NCoR2 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 300 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Research Kits | ||
| EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
| NCOA3 | NCoA4 | NCOR1 | ncor2 |
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 More > |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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