| Cat.No.: | EAb-2000 |
| Antibody Type: | Polyclonal |
| Immunogen: | This ERR-alpha antibody was raised against a peptide within the C-terminal region of human ERR alpha. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 50 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:1,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | ERR-α (Estrogen-related receptor alpha, NR3B1) is an orphan nuclear receptor similar to the Estrogen Receptor. It is a sequence-specific DNA binding transcriptional activator that is constitutively active in the absence of ligand binding. No true physiological ligands have been found, but estrogen-like compounds from plants have been shown to activate ERR-α. ERR-α and ER-α have been found to regulate an overlapping set of genes, and ERR-α appears to modulate the activity of ER-α in some tissue types. ERR-α regulates genes involved in mitochondrial biogenesis, gluconeogenesis, oxidative phosphorylation, and fatty acid metabolism. ERR-α knockout mice display impaired fat metabolism and absorption. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0413 | ERG Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0421 | Human ERCC6 Knockout Cell Line 26bp deletion | Inquiry |
| CL-0422 | Human ERCC6-PGBD3 Knockout Cell Line | Inquiry |
| CL-0423 | Human ERCC6L Knockout Cell Line 2bp deletion | Inquiry |
| CL-0428 | Human ERCC8 Knockout Cell Line 7bp deletion | Inquiry |
| Related Gene / Proteins | |||
| ERCC6 | ERCC6L | ERCC8 | ERG |
| ERI3 | ERR-α | ||
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