| Cat.No.: | EAb-1867 |
| Antibody Type: | Polyclonal |
| Immunogen: | This PGC1-β antibody antibody was raised against a peptide within the N-terminal region of human PGC1-β. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 150 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | PGC1-β (Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PPARGC1B, PERC) is a co-activator of transcription by nuclear receptors and transcription factors. PGC1-β participates in modulating the transcriptional activity of PPAR alpha and gamma, ER alpha, NRF1 and GR. It is likely involved in fat oxidation, non-oxidative glucose metabolism and in the regulation of energy expenditure. Expression of PGC1-β is repressed by saturated fatty acids in skeletal muscle cells and induced by insulin. PGC1-β is down-regulated in type 2 diabetes as well as in pre-diabetics. Allelic variation of PGC1-β may contribute to the pathogenesis of obesity, with the widespread Ala-203 variation being a significant risk factor for the development of this diabetes. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0422 | Human ERCC6-PGBD3 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-1867 | PGC1-β Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| PGBD3 | PGC1-β | ||
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