| Cat.No.: | EAb-1788 |
| Product Name: | TDG / Thymine-DNA glycosylase Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a full-length recombinant protein corresponding to mouse thymine DNA glycosylase (TDG). |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 55 kDa |
| Purification: | Protein A Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:1,500 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. In addition, TET proteins oxidize 5- methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5- formylcytosine (5fC), and 5-carboxylcytosine (5caC). TDG / Thymine-DNA glycosylase functions to correct G/T mispairs to G/C pairs and plays a role in active DNA demethylation by recognizing 5fC and 5caC and converting these to cystosine through the base excision repair (BER) pathway. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0016 | TDRD4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0049 | Recombinant Human TDRD3 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0285 | Human TDG Knockout Cell Line 2bp insertion | Inquiry |
| CL-0286 | Human TDGF1 Knockout Cell Line | Inquiry |
| CL-0431 | Human TDP1 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TDF | TDG | TDGF1 | TDP1 |
| TDRD12 | TDRD3 | TDRD4 | TDRD4 |
| TDT | |||
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