| Cat.No.: | EAb-1694 |
| Antibody Type: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA, IHC, WB |
| Recommended Dilutions/Conditions: |
ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, STAMBP, AMSH |
| Scientific Background: | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0164 | Human ST14 Knockout Cell Line | Inquiry |
| CL-0272 | Human STAMBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0273 | Human STAMBPL1 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0279 | Human STAMBPL1 Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0178 | ST18 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ST14 | ST18 | STAG1 | STAMBP |
| STAMBPL1 | STAT1 | STAT2 | STAT3 |
| STAT4 | STAT5A | STAT5B | STAT6 |
| STAU2 | STYXL1 | ||
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