| Cat.No.: | EAb-1198 |
| Antibody Type: | Polyclonal |
| Conjugate: | HRP |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | PSME3 , 11S regulator complex subunit gamma, Short name=REG-gamma, Activator of multicatalytic protease subunit 3, Ki nuclear autoantigen, Proteasome activator 28 subunit gamma, PA28g, PA28gamma |
| Scientific Background: | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0120 | Human PSMB9 Knockout Cell Line 4bp deletion | Inquiry |
| CL-0122 | Human PSMB8 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0166 | Human PSG1 Knockout Cell Line | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0904 | Recombinant Zebrafish PSME4B | Inquiry |
| ◆ Antibodies | ||
| EAb-1167 | PSMG3 Polyclonal Antibody, HRP Conjugated | Inquiry |
| Related Gene / Proteins | |||
| PSD3 | PSG1 | PSMA7 | PSMB1 |
| PSMB2 | PSMB4 | PSMB7 | PSMB8 |
| PSMB9 | PSMC3 | PSMC6 | PSMD10 |
| PSMD11 | PSMD2 | PSMD7 | PSME2 |
| PSME3 | PSME4B | PSMF1 | PSMG3 |
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