| Cat.No.: | EAb-0650 |
| Product Name: | DNMT3L Monoclonal Antibody [B0-5] |
| Antibody Type: | Monoclonal |
| Conjugate: | Unconjugated |
| Host: | Mouse |
| Isotype: | IgG1 |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 1*TBS (pH7.4), 0.5% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Applications: | ICC, IHC |
| Recommended Dilutions/Conditions: |
ICC: 1:200-1:500, IHC: 1:200 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | DNA Cytosine 5 Methyltransferase 3 Like Protein antibody, DNA Methyltransferase 3 Like Protein antibody, DNM3L_HUMAN antibody, Dnmt 3L Antibody, Human Cytosine 5 Methyltransferase 3 like protein antibody, MGC1090 antibody, Anti DNMT3L Molyclonal [B0-5], DNMT3L Monoclonal Antibody |
| Scientific Background: | DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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