| Cat.No.: | EAb-0623 |
| Product Name: | p53 Monoclonal Antibody |
| Product Overview: | Anti-p53 (MOUSE) Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | Produced by repeated immunizations with recombinant human p53 protein. |
| Host: | Mouse |
| Isotype: | IgG2a |
| Purification: | Protein A purified |
| Appearance: | Liquid |
| Formulation: | 0.02 M Potassium Phosphate, 0.5 M Sodium Chloride, pH 7.2 |
| Applications: | ChIP, flow cytometry, immunohistochemistry, Immunofluorescence, immunoblotting and immunoprecipitation |
| Recommended Dilutions/Conditions: |
ELISA: 1:2,000 - 1:10,000 ChIP: 1 µg/µL; IF Microscopy: 1:100-1:500; Western Blot: 1:500 - 1:2,000; Immunohistochemistry: 1:50 ImmunoPrecipitation: 1:100 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Cross Reactivity: | human |
| Shipping: | Dry Ice |
| Storage: | -20°C |
| Storage Buffer: | 0.01% (w/v) Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | NCBI - 23491729; UniProtKB - P04637; GeneID - 7157 |
| Alternative Name: | mouse anti-p53 antibody, mouse anti-Tumor Suppressor p53 antibody, Phosphoprotein p53 antibody, TP53 antibody, Transformation related protein 53 antibody, TRP53 antibody, cellular Tumor antigen p53 antibody |
| Scientific Background: | The p53 gene like the Rb gene, is a tumor suppressor gene. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism; its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are pre-disposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood. This condition is rare, and is known as Li-Fraumeni syndrome. However, mutations in p53 are found in most tumor types, and so contribute to the complex network of molecular events leading to tumor formation. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0013 | TP2 Polyclonal Antibody | Inquiry |
| EAb-0623 | p53 Monoclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0053 | UNC-2170 | Inquiry |
| BSM-0324 | UNC2170 (maleate) | Inquiry |
| ◆ Cell Lines | ||
| CL-0438 | Human TP53BP1 Knockout Cell Line 40bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TP2 | TP53BP1 | ||
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