| Cat.No.: | EAb-0569 |
| Product Name: | HDAC2 Phospho S394 Polyclonal Antibody |
| Product Overview: | Anti-HDAC2 pS394 (RABBIT) Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Produced in rabbits by repeated immunizations with a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser394 of human HDAC2. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. |
| Appearance: | Liquid |
| Formulation: | 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5 |
| Applications: | Western Blots and is specific for the ~55 kDa HDAC2 protein phosphorylated at Ser394 in Western blots |
| Recommended Dilutions/Conditions: |
ELISA: 1:10,000; Western Blot: 1:1000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Cross Reactivity: | mouse, rat |
| Shipping: | Wet Ice |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | UniProtKB - Q92769; GeneID - 3066; NCBI - NP_001518.3 |
| Alternative Name: | Histone Deacetylase 2, HD2 |
| Scientific Background: | Histone Deacetylase 2 (HDAC2) is part of a family of histone deacetylases that are responsible for deacetylation of lysine residues in the histone core. HDAC2 is classified as a class I histone deacetylase and is ubiquitously expressed throughout the body. It has been shown that HDAC2 plays an important role in cardiac hypertrophy. Phosphorylation of ser394 is responsible for the hypertrophy-associated activation of HDAC2, whereas intrinsic basal activity is maintained by phosphorylation of ser422 and ser424. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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