| Cat.No.: | EAb-0397 |
| Product Name: | KEAP1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthesized peptide derived from the Internal region of human Keap1. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB, IHC-p, ELISA |
| Recommended Dilutions/Conditions: |
WB: 1:500-1:2000; IHC: 1:100-300; ELISA: 1:20000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Rat |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q14145 |
| Alternative Name: | Cytosolic inhibitor of Nrf2,INrf 2,INrf2,Keap 1,KEAP1,KEAP1,Kelch like ECH associated protein 1,Kelch like family member 19,Kelch like protein 19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,KIAA0132,KLHL 19,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454 |
| Scientific Background: | Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0320 | KEAP1 Polyclonal Antibody | Inquiry |
| EAb-0397 | KEAP1 Polyclonal Antibody | Inquiry |
| EAb-1323 | KEAP1 Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1324 | KEAP1 Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1325 | KEAP1 Polyclonal Antibody, Biotin Conjugated | Inquiry |
| Related Gene / Proteins | |||
| KEAP1 | |||
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