| Cat.No.: | EAb-0338 |
| Product Name: | Histone H2B Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | Synthetic Peptide |
| Host: | Mouse |
| Isotype: | IgG |
| Purification: | Protein A purification |
| Appearance: | Liquid |
| Applications: | WB, IF |
| Recommended Dilutions/Conditions: |
WB: 1:1000-3000; IF: 1:100-200 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Rat |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P33778 |
| Alternative Name: | HIST1H2BA,testis,bA317E16.3,H2B,H2B histone family member U,H2B histone family member U testis specific,H2B histone family,member U,(testis specific),H2B testis,H2B1A,H2BFU,H2BT,HIST1H2BA,Histone 1,H2ba,Histone cluster 1 H2ba,Histone H2B,Histone H2B testis,Histone H2B type 1 A,Histone H2B type 1-A,Histone H2B type 1A,STBP,Testis specific histone H2B,Testis-specific histone H2B,TSH 2B,TSH2B,TSH2B.1 |
| Scientific Background: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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