| Cat.No.: | EAb-0319 |
| Antibody Type: | Polyclonal |
| Immunogen: | A synthetic peptide of mouse SIRT6 |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
WB: 1:500 - 1:2000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q8N6T7 |
| Alternative Name: | 2810449N18Rik,AI043036,Mono ADP ribosyltransferase sirtuin 6,NAD-dependent protein deacetylase sirtuin-6,Regulatory protein SIR2 homolog 6,Regulatory protein SIR2 homolog,SIR2 like 6,SIR2 like protein 6,Sir2 related protein type 6,SIR2-like protein 6,SIR2L6,SIR6,SIRT 6,SIRT6,Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae),Sirtuin 6,Sirtuin type 6,Sirtuin6 |
| Scientific Background: | This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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