| Cat.No.: | EAb-0255 |
| Product Overview: | Rabbit monoclonal (RM236) to detect 5-hydroxymethylcytosine (5-hmC) |
| Antibody Type: | Monoclonal |
| Clone Designation: | RM236 |
| Immunogen: | BSA-conjugated 5-hydroxy methylcytosine |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein A purified |
| Appearance: | Liquid |
| Formulation: | 0.09% Sodium azide, 50% Glycerol, 1% BSA, PBS |
| Applications: | Dot blot, ELISA, hMeDIP, ICC, and IHC |
| Species Reactivity: | All species |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Storage Buffer: | 50% glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | 5-hmC |
| Scientific Background: | DNA methylation of cytosine to 5-methylcytosine (5-mC) is an epigenetic mark that is relatively common in both plants and mammals and plays a role in transcriptional and chromatin regulation. It is also known that the Tet family of enzymes can catalyze the oxidation of 5-mC to 5-hydroxy methylcytosine (5-hmC), which may be a step in the demethylation of 5-mC, as no DNA demethylases are known. In healthy cells, DNA methylation occurs at CpG sites, but CpG islands are generally not modified. However, tumor cells show an increase in CpG island methylation and a decrease in individual CpG sites. This ‘hypo-methylation’ can lead to aberrant activation of genes. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0001 | 5-Hydroxymethylcytosine (5-hmC) Polyclonal Antibody | Inquiry |
| EAb-0209 | 5-Hydroxymethyluridine Polyclonal Antibody | Inquiry |
| EAb-0226 | 5-Hydroxymethylcytosine (5-hmC) Polyclonal Antibody | Inquiry |
| EAb-0254 | 5-Methylcytosine (5-mC) Monoclonal Antibody (RM231) | Inquiry |
| EAb-0255 | 5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| 5-caC | 5-fC | 5-hmC | 5-Hydroxymethyluridine |
| 5-mC | 5-mCpA | ||
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