| Cat.No.: | EAb-0254 |
| Product Overview: | Rabbit monoclonal (RM231) to detect 5-methylcytosine (5-mC) |
| Description: | Anti-5-methyl Cytosine Rabbit Monoclonal Antibody (Clone RM231) is a probe for immunochemical detection of 5-methyl cytosine by methylated DNA immunoprecipitation, IHC, ICC, ELISA, or dot blot. |
| Antibody Type: | Monoclonal |
| Clone Designation: | RM231 |
| Immunogen: | Chemical/ Small Molecule corresponding to 5-methylcytosine (5-mC) conjugated to Bovine Serum Albumin (BSA). |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein A purified |
| Appearance: | Liquid |
| Formulation: | 0.09% Sodium azide, 50% Glycerol, 1% BSA, 48% PBS |
| Applications: | MeDIP, ELISA, IHC-P, Flow Cyt, ICC, Dot blot |
| Species Reactivity: | Species independent |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Storage Buffer: | 50% glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | 5-methylcytosine, 5-methyl cytosine |
| Scientific Background: | DNA methylation of cytosine to 5-methyl cytosine (5-mC) is an epigenetic mark that is relatively common in both plants and mammals and plays a role in transcriptional and chromatin regulation. In healthy cells, DNA methylation occurs at CpG sites, but CpG islands are generally not modified. However, tumor cells show an increase in CpG island methylation and a decrease in individual CpG sites. This ‘hypo-methylation’ can lead to aberrant activation of genes. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0001 | 5-Hydroxymethylcytosine (5-hmC) Polyclonal Antibody | Inquiry |
| EAb-0209 | 5-Hydroxymethyluridine Polyclonal Antibody | Inquiry |
| EAb-0226 | 5-Hydroxymethylcytosine (5-hmC) Polyclonal Antibody | Inquiry |
| EAb-0254 | 5-Methylcytosine (5-mC) Monoclonal Antibody (RM231) | Inquiry |
| EAb-0255 | 5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| 5-caC | 5-fC | 5-hmC | 5-Hydroxymethyluridine |
| 5-mC | 5-mCpA | ||
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