| Cat.No.: | EAb-0191 |
| Product Name: | HDAC6 Monoclonal Antibody (D1 domain-specific) |
| Product Overview: | Mouse monoclonal antibody to detect HDAC6 (D1 Domain) in human samples |
| Description: | The affinity purified mouse monoclonal antibody is immunospecific for the D1 domain (a.a. 281-291) of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. |
| Antibody Type: | Monoclonal |
| Immunogen: | Human Histone deacetylase 6 (HDAC6; sequence NP_006035.2, UniProtKB - Q9UBN7) |
| Host: | Mouse |
| Isotype: | IgG |
| Antibody Target: | HDAC6 |
| Purification: | Affinity purified from hybridoma culture supernatant (Protein A) |
| Appearance: | Colorless Liquid |
| Formulation: | 1 mg/ml in PBS, pH 7.4, 0.02% sodium azide |
| Applications: | ELISA, IC/IF |
| Recommended Dilutions/Conditions: |
ELISA: 1 – 10µg/ml; Immunocytochemistry/Immunofluorescence: 10 – 50 µg/ml Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | HEK293T cells |
| Species Reactivity: | Human |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9UBN7 |
| Alternative Name: | KIAA0901, JM21, HD6, HDAC6-D1 |
| Scientific Background: | HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including α-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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