| Cat.No.: | EAb-0042 |
| Product Name: | Runx1/AML1-ETO Polyclonal Antibody |
| Product Overview: | Polyclonal Antibody to detect Runx1-ETO in human, mouse and a wide range of samples. |
| Description: | This antibody specifically recognizes the AML1 (RUNX1) - ETO (RUNX1T1) fusion protein that arises due to a translocation between chromosome 8 and 22 (t(8;21)(q22;q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukemia. It produces a chimerical gene made up of the 5’-region of AML1and the 3’-region of ETO. The chimerical protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. |
| Antibody Type: | Polyclonal |
| Immunogen: | Polyclonal antibody raised in rabbit against the Runx1-ETO fusion protein using a KLH-conjugated synthetic peptide. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | Runx1/AML1-ETO |
| Purification: | Whole Anti-Sera |
| Appearance: | Colorless liquid |
| Formulation: | In PBS with 0.05% (W/V) sodium azide. |
| Applications: | Western blot, ELISA, ChIP. |
| Recommended Dilutions/Conditions: |
ChIP: 4 µg/ChIP, WB: 1:1000, ELISA: 1:500 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western blot: SKNO-1 cells, ELISA: Peptides, ChIP: Kasumi cells. |
| Species Reactivity: | Human |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q01196 |
| Alternative Name: | AML1-ETO |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0042 | Runx1/AML1-ETO Polyclonal Antibody | Inquiry |
| EAb-0313 | RUNX2 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0092 | Recombinant Human RUNX2 293 Cell Lysate | Inquiry |
| EL-0093 | Recombinant Human RUNX2 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0746 | Recombinant Human RUNX2 | Inquiry |
| Related Gene / Proteins | |||
| Runx1 | RUNX2 | RUVB2 | RUVBL1 |
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