GSK3326595

Cat.No.:	BSM-0397
Product Name:	GSK3326595
CAS No.:	1616392-22-3
Figure:
Product Overview:	A PRMT5 inhibitor
Description:	GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits methylation of peptides derived from the PRMT5 substrates histone H4 and H2A, SmD3, FUBP1, and HNRNPH1 by the PRMT5/MEP50 complex with IC50 values ranging from 5.9 to 19.7 nM and is more than 4,000-fold selective for PRMT5/MEP50 over a panel of 20 methyltransferases. GSK3326595 (200 nM) induces alternative splicing of MDM4 in Z-138, MCF-7, JM1, and DOHH-2 cells and increases p53 and p21 protein levels in Z-138 cells in a concentration-dependent manner. GSK3326595 inhibits growth and symmetric dimethyl arginine (SDMA) methylation in several lymphoma and breast cancer cell lines. It also reduces tumor growth in a Z-138 mouse xenograft model when administered at doses of 25, 50, and 100 mg/kg twice per day.
Appearance:	A solid
Molecular Weight:	452.6
Purity:	≥98%
Storage:	-20°C
Targets:	PRMT5
Molecular Formula:	C24H32N6O3
Chemical Name:	6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyrimidinecarboxamide
Warning:	For Research Use Only! Not For Use in Humans.

Online Inquiry

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Products