| Cat.No.: | BSM-0383 |
| CAS No.: | 2889-31-8 |
| Figure: |
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| Synonyms: | 2-HG; 2-Hydroxyglutaric Acid |
| Product Overview: | An α-hydroxy acid |
| Description: | α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid.1,2,3 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.4,5 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases. |
| Appearance: | A solution in ethanol |
| Molecular Weight: | 148.1 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | Histone lysine and DNA demethylation |
| Molecular Formula: | C5H8O5 |
| Chemical Name: | 2-hydroxy-pentanedioic acid |
| Warning: | For Research Use Only! Not For Use in Humans. |
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