| Cat.No.: | BSM-0369 |
| CAS No.: | 13095-48-2 |
| Figure: |
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| Synonyms: | 2(S)-HG; 2(S)-Hydroxyglutaric Acid; L-2-HG; L-2-Hydroxyglutaric Acid |
| Product Overview: | An α-hydroxy acid |
| Description: | L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation. |
| Appearance: | A solution in ethanol |
| Molecular Weight: | 148.1 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | Histone lysine and DNA demethylation |
| Molecular Formula: | C5H8O5 |
| Chemical Name: | 2S-hydroxy-pentanedioic acid |
| Warning: | For Research Use Only! Not For Use in Humans. |
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