| Cat.No.: | BSM-0344 |
| CAS No.: | 1962928-21-7 |
| Figure: |
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| Product Overview: | An inhibitor of the CBP and p300 bromodomains |
| Description: | PF-CBP1 is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively). It displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins. PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages. It also suppresses the expression of RGS4 (regulator of G protein signaling) in primary cortical neurons. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 488.6 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | CBP; p300 |
| Molecular Formula: | C29H36N4O3 |
| Chemical Name: | 5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-benzimidazole |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | EP300 | EPC1 |
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