| Cat.No.: | BSM-0319 |
| CAS No.: | 315704-66-6 |
| Figure: |
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| Product Overview: | A BMI-1 inhibitor |
| Description: | Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth. It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 495.2 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | Polycomb complex protein BMI-1 |
| Molecular Formula: | C17H13Br2N5OS |
| Chemical Name: | N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0033 | Human COMMD3-BMI1 Knockout Cell Line | Inquiry |
| CL-0034 | Human BMI1 Knockout Cell Line 11bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0164 | BMI1 Polyclonal Antibody | Inquiry |
| EAb-0165 | BMI1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0319 | PTC-209 | Inquiry |
| Related Gene / Proteins | |||
| BMI1 | |||
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